Abstract: Hypoxia is a frequently encountered condition at high altitude. Hypoxia-inducible factor-1 modulates vascular endothelial growth factor, glucose transporter, angiogenin and fibroblast growth factor in hypoxic condition. The aim of the study was to evaluate the promising benefits of bromelain (BR; 7 μg/ml) against cobalt chloride (CoCl2; 100 mM) induced hypoxia in Caco-2 cell line. The inference drawn from the study was CoCl2-induced hypoxia regulates hypoxia-inducible factor-1 by normalizing oxidative insult, which further leads to changes in cell morphology, DNA damage and apoptosis. BR pre-treated cell line has shown a noteworthy protection against CoCl2-induced cell morphology and apoptotic cell death. The study also confirms that the supplementation of BR could be helpful in regulating appetite at high altitude environments.
Keywords: Hypoxia, Cobalt chloride, HIF-1α, Bromelain.
Title: Ameliorative effects of bromelain on cobalt chloride-induced hypoxia in Caco-2 cell line
Author: Anusha M B, Naveen S, Phani Kumar G, Anilakumar K R
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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