Abstract: Background: Growing evidence suggests the involvement of angiotensin-converting enzyme 2 (ACE2) in lipid metabolism and cardiovascular homeostasis. Genetic variations in ACE2 have been linked to metabolic disorders, including dyslipidemia, which is a hallmark of type 2 diabetes mellitus (T2DM). However, the association of ACE2 polymorphisms and dyslipidemia in T2DM patients, particularly in Iraqi populations, remains underexplored.
Aim: This study aimed to investigate the association of ACE2 gene polymorphisms (rs2285666 and rs4646142) with dyslipidemia in Iraqi patients with T2DM, stratified by sex.
Methods: A case-control study was conducted involving 463 T2DM patients (222 women and 241 men). Based on serum lipid profiles, participants were stratified into dyslipidemic (cases) and non-dyslipidemic (control) groups. Genotyping of ACE2 polymorphisms was performed using PCR-based methods, and serum ACE2 levels were quantified using ELISA.
Results: The AA genotype of rs2285666 SNP was significantly associated with dyslipidemia in women (OR = 3.19, 95% CI = 1.31–7.78, p = 0.01), while the A allele was associated with dyslipidemia in men (OR = 2.36, 95% CI = 1.27–4.39, p = 0.006). High ACE2 levels, elevated atherogenic indices, and adverse lipid profiles were observed in carriers of the A allele. No significant association was found for rs4646142 SNP.
Conclusion: The rs2285666 SNP was associated with dyslipidemia in Iraqi T2DM patients, with sex-specific differences in risk. The ACE2 variants may contribute to dyslipidemia pathogenesis in T2DM and highlight the potential for personalized risk stratification and therapeutic targets.
Keywords: ACE2, rs2285666, rs4646142, Dyslipidemia, T2DM, Association.
Title: Association of ACE2 Gene Polymorphisms (rs2285666 and rs4646142) with Dyslipidemia in Iraqi Patients with Type 2 Diabetes Mellitus A Sex-Stratified Analysis
Author: Ali B. Abulrazzaq, Ibrahim Rahem Jassim Al-Aadily, Maha Radhi Abass, Majid Kadhum Hussain
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Vol. 13, Issue 2, April 2025 - June 2025
Page No: 1-10
Research Publish Journals
Website: www.researchpublish.com
Published Date: 04-April-2025
