Abstract: Background: Type 2 diabetes mellitus (T2DM) is a multifactorial disease often accompanied by dyslipidemia, a major cardiovascular risk factor. Genetic variations in the LDL receptor (LDLR) gene have been implicated in lipid metabolism abnormalities. This study investigates the association of LDLR polymorphisms with dyslipidemia in Iraqi T2DM patients.
Methods: A case-control study was conducted with 420 type 2 diabetics: 210 patients with dyslipidemia (Cases) and 210 without served as a control group. Serum lipid levels were measured, and LDLR rs688 and rs2228671 SNPs were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.
Results: The variant genotype of the rs688 SNP was significantly associated with dyslipidemia in T2DM patients under the codominant (OR= 1.96, P= 0.018), dominant (OR= 1.62, P= 0.011) and recessive (OR= 1.96, P= 0.018) models. Also, the variant genotype of the rs2228671 SNP was significantly associated with dyslipidemia under the codominant (OR= 1.49, P= 0.043), dominant (OR= 1.62, P= 0.011) and recessive (OR=1.96, P=0.018) models. Carriers of the TT genotypes of the two SNPs exhibited lower HDL-c levels than those of the reference genotypes.
Conclusion: Carriers of the variant genotypes of the rs688 and rs2228671 SNPs have a 1.5-to 2-fold risk of dyslipidemia development relative to those with wild genotypes. The TT genotype is implicated in lowering high-density lipoprotein-cholesterol (HDL-c). The study explores the importance of identifying at-risk individuals and guiding personalized lipid-lowering interventions to reduce cardiovascular complications in T2DM.
Keywords: LDL receptor, T2DM, Dyslipidemia, rs688, rs2228671.
Title: Association of LDL Receptor Polymorphisms with Dyslipidemia in Type 2 Diabetes Mellitus: Insights from the Iraqi Population
Author: Thualfeqar G M Almohanna, Ibrahim Rahem Jassim Al-Aadily, Maha Radhi Abass, Majid Kadhum Hussain
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
Vol. 13, Issue 1, April 2025 - September 2025
Page No: 16-23
Research Publish Journals
Website: www.researchpublish.com
Published Date: 04-April-2025
