Abstract: A. baumannii has been designated as a “red alert” human pathogen, generating among the medical fraternity, arising largely from its extensive antibiotic resistance spectrum. Carbapenem resistance in Acinetobacter is now observed increasingly, and constitutes a sentinel event for emerging antimicrobial resistance. The production of carbapenem hydrolyzing beta-lactamases is the most common mechanism responsible for carbapenem resistance. Design: This prospective study was conducted in the Department of Microbiology, Pt. B.D. Sharma PGIMS, Rohtak from December 2012-November 2013, on 100 isolates of Acinetobacter baumannii. The specimens were process for bacteriological cultures, biochemical reactions and antigenic sensitivity against Antibiotic [Imipenem, Meropenem and Doripenem (Carbapenem group)] by kirby-bauer method. P value <0.05 was statistically significant. Results: Out of 42141 samples 855 (7.75%) specimen shows A. baumannii growth. Male to female ratio was 1.70:1. Patients belonged to age 51-60 years (29%) and 76% with ICU. The endo-tracheal aspirate isolates were 66%. Isolates were sensitive to Carbapenem group followed by imipenem (81%), Meropenem (39%) and doripenem (40%). On comparing the resistance to carbapenems P value were significant in imipenem, meropenem and Doripenem, i.e. <0.05. Conclusion: Treatment of Acinetobacter infection should be prescribed on the basis of antimicrobial sensitivity reports and judicious way to decrease the emergence of drug resistant isolate. Sharing of expertise and collaboration between the clinicians using antibiotic therapy and microbiologist may be the simplest health measure to optimise the use of antibiotics.
Keywords: Carbapenems, Acinetobacter baumannii, ICU, UTI, BAL, ETA, ET, Lower respiratory tract sample.
Title: Effect of Carbapenems on Clinical Isolates of Acinetobacter baumannii spp. in Tertiary Care Hospital of North India
Author: Ravi Kumar, Nidhi Goel, Yogesh Kumar, Uma Chaudhary
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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