Abstract: Gonadal hormones are responsible for the control of fertility. The understanding of their regulation is vital in solving reproductive problems such as infertility. The level at which people indiscriminately use medicinal plants due to financial and cultural factors for treating illnesses such as infertility without regards for their possible adverse effects has not been fully explored. This study was therefore conducted to determine the effects of partially purified bioactive compounds in leave extract of Jatropha tanjorensis on the gonadal hormones of male albino rats. The study was carried out using 20 male albino rats in 3 control groups and 2 treatment groups of 4 rats each. 25 mg/Kg body weight of the isolates Phytol and Lupeol were orally administered using intubation cannula for 14 days. The rats were anaesthetized with phenobarbital; blood samples collected and analyzed for hormonal assay at different intervals. No significant changes (p˂0.05) in the body weights or the testis. However, the epididymal sperm count and motility was found significantly different when compared tosustanaon-control rats. The bioactive compounds lupeol and phytol present in Jatrophat anjorensis leaves extract are antifertility agents as seen by the significant changes in the parameters studied and the semen analysis carried out.
Keywords: Jatropha tanjorensis, Lupeol, Phytol and gonadal hormones.
Title: Effects of partially purified bioactive compounds in leaves extract of Jatropha tanjorensis on gonadal hormones of male albino rats
Author: J. Akighir, B. Inalegwu, F. N. Onyezili
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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