Abstract: Hypothyroidism is associated with significant symptoms and an adverse effect on the quality of life. There exists a central homeostatic mechanism in the adult mammalian brain to defer these adverse neuropsychological manifestations, for some days. Thyroid hormone is known to affect the activities of some enzymes involved in neurotransmission. In this study, a reflection of the physiological consequences of ‘central thyroid hormone homeostasis’ has been addressed with the study of the activities of the synaptosomal membrane Na+-K+-ATPase and Ca2+/Mg2+-ATPase on the days of onset and termination of the homeostatic phenomenon. Moreover, certain adrenergic receptor (α2- and β-) agonists and antagonists have profound influence on synaptosomal thyroid hormone levels during the days of initiation and termination of the ‘central homeostasis’. This notion has further prompted us to investigate the effects of these compounds on Na+-K+-ATPase and Ca2+/Mg2+-ATPase during the start and end days of this central homeostatic phenomenon. The altered activities of these enzymes on these two days point towards their dependency on cerebral thyroid hormone levels and thus the hormonal involvement in neurobiochemical events. The entire phenomenon of homeostasis thus appears to be a stress-mediated event involving an array of adrenergic non-genomic effects, further indicating a nongenomic role of thyroid hormone during homeostasis.
Keywords: Synaptosome, Na+-K+-ATPase, Ca2+/Mg2+-ATPase, thyroid hormone, homeostasis.
Title: Evaluating the role of Adrenergic compounds on Synaptosomal Na+-K+-ATPase and Ca2+/Mg2+-ATPase during Central Thyroid Hormone Homeostasis
Author: Samita Kundu, Sumedha Roy, Angshuman Biswas, Arun K. Ray
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Vol. 10, Issue 2, April 2022 - June 2022
Page No: 33-40
Research Publish Journals
Website: www.researchpublish.com
Published Date: 31-May-2022
