Abstract: Diabetes mellitus is one of the oldest non-communicable diseases affecting a greater proportion of the world’s population. Uvaria chamae is a medicinal plant with various health benefits. The study evaluated the fasting plasma glucose (FPG), lipid profile and atherogenic index of plasma (AIP) in diabetic rats treated with aqueous extract of U. chamae leaves. Diabetes was induced with alloxan monohydrate (150mg/kg body weight) intraperitoneally. Thirty (30) albino wistar rats were randomly assigned into 5 groups (I-V) of 6 rats each. Groups I and II were the control (non-diabetic) and diabetic groups respectively, and received 0.5ml distilled water. Groups III, IV and V were diabetic rats treated with 100mg/kg, 300mg/kg and 500mg/kg of aqueous extract of U. chamae leaves respectively for 28 days. The leaves were washed, air-dried, pulverized and macerated in distilled water for 48 hours with intermittent agitations followed by sieving and evaporation of the filtrate to dryness, and reconstitution with distilled water prior to oral administration in the rats. The mean FPG level of group II was significantly higher when compared with groups I, III, IV and V (p<0.05). Additionally, there was a dose-dependent reduction in the FPG levels of rats treated with the extract. The mean levels of total cholesterol (TC), low density lipoprotein cholesterol (LDLC), very low density lipoprotein cholesterol (VLDLC), triglyceride (TG) and AIP were significantly higher while high density lipoprotein cholesterol (HDLC) was significantly lower in group II when compared with group I (p<0.05). There were significant reductions in TC, LDLC, TG and AIP as well as a significant increase in HDLC in group V when compared with groups II, III and IV (p<0.05), although the reduction in VLDLC and TG were not significant in group V compared with that of group IV. The aqueous extract of U. chamae leaves may possess anti-diabetic and anti-atherogenic properties, hence, may be useful in the management of diabetes and reduction of cardiovascular disease risk.
Keywords: Fasting Plasma Glucose, Uvaria chamae, Lipid Profile, Diabetes mellitus, Atherogenic Index of Plasma.
Title: Evaluation of Fasting Plasma Glucose, Lipid Profile and Atherogenic Index of Diabetic Rats treated with Aqueous Extract of Uvaria chamae Leaves
Author: Chikaodili N. Obi-Ezeani, Amuche L. Onuike, Ifeoma J. Onuora, Claire A. Ewelugo, Onyema A. Onyegbule, Obiageli B. Onyema-Iloh, Obiageli E. Nnoruka, Ijeoma J. Nwagbara
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Vol. 11, Issue 3, July 2023 - September 2023
Page No: 24-29
Research Publish Journals
Website: www.researchpublish.com
Published Date: 01-August-2023
