Abstract: Medicinal plants play a major role in the discovery of new therapeutic agents for drug development. In recent times, bioactive compounds derived from plants have a dynamic role to play in prevention of various human diseases. Memecylon flavescens, is an endangered taxon belongs to the family Melastomataceae. The present study is an attempt to investigate the presence of phytochemicals in methanolic extracts of stem and leaf by GC/MS and to estimate the content of total phenols and flavonoids. In addition, antioxidant potential of the extracts was analysed by various standard in vitro assays. Results have shown that stem contains 32.73 ± 0.079 mg/g of phenols and 13.56 ± 0.062 mg/g of flavonoids, while the extract of leaf has 25.89 ± 4.97 mg/g of phenols and 10.18 ± 0.318 mg/g of flavonoids. The GC/MS analysis has revealed the presence of 37 compounds in stem and 27 compounds in leaf. A few compounds are found to be common in both the extracts with 2(5H)-Furanone, 3-Methyl-5-Methylene, a ketone group as a major compound with peak area of 19.20 % in stem extract and 33.82% in leaf extract. Whereas, 3, 5-Dimethoxy-4-Hydroyphenethylamine, a amine group has shown a least percent of peak area of 0.45% in stem extract and 4-Methyl-2, 5-Dimethoxybenzaldehyde, an aldehyde group with 0.56% in leaf extract. The extracts were screened for potential antioxidant activity by DPPH, ABTS, and reducing power capacity. Free radical scavenging potentials of the extracts at various concentrations were tested. The stem extract has shown higher scavenging activity than the leaf extract. A strong reducing power capacity was observed for methanolic extract of stem. The antioxidant potential of the stem and leaf extracts were correlated with the total phenols and flavonoids. The study has highlighted the antioxidant potential of the stem extract, thereby exploring the promising application in pharmaceuticals.
Keywords: Memecylon flavescens, Endangered, GC-MS, Phytochemical, Antioxidant.
Title: Evaluation of phytochemical and antioxidant analysis of Memecylon flavescens - an endangered taxon
Author: D.H.Tejavathi, B.S.Sumalatha, R. Nijagunaiah, P.Anitha, K.Gayatramma
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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