Abstract: Homology modeling [4] aims to build three-dimensional protein structure [2] models using experimentally determined structures of related family members as templates. SWISS-MODEL [13] workspace is an integrated Web-based modeling [11] expert system. For a given target protein, a library of experimental protein structures is searched to identify suitable templates. On the basis of a sequence alignment [23][24] between the target protein and the template structure, a three-dimensional model for the target protein is generated. Model quality assessment tools are used to estimate the reliability of the resulting models. Homology modeling [4] is currently the most accurate computational method [3] to generate reliable structural models and is routinely used in many biological applications.
Title: HOMOLOGY MODELING OF ALPHA- SYNUCLEIN (SNCA) PROTEIN OF HUMAN
Author: Anubrata Paul, Souvik Mondal
International Journal of Life Sciences Research
ISSN 2348-3148 (online), ISSN 2348-313X (Print)
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