Abstract: Acute pancreatitis (AP) is one of the most common gastrointestinal diseases in hospitalized patients. Numerous severity indicators have been described till date, most of which require reassessment after admission and resuscitation. Neutrophil-to-lymphocyte ratio (NLR) is a biological marker that has been shown to predict the mortality of Acute Pancreatitis. Current scoring systems for AP diagnosis are complicated, whereas NLR is a simple, practical, and effective marker.
Objectives: To evaluate NLR as an independent prognostic factor for mortality among adults with AP
Methods: We screened cohort studies through Cochrane, Embase, Medline, PubMed in investigating the association between NLR and mortality in AP adult patients up to June, 2020. The primary outcome was mortality. Pooled risk ratio, sensitivity, specificity, and an area under the receiver operating characteristic curve (AUC) was performed by a statistician
Results: Out of the 151 studies searched, there were 5 studies (N= 1999) which met the inclusion criteria for this meta-analysis. Forrest plot analysis showed that elevated NLR (> 12) is associated with 11.5 times increased risk of dying among adult patients with AP (p-value<0.0001, 95%CI: 6.86 to 19.54). NLR has a pooled high sensitivity of 86 %; (p value 0.85, 95%, CI: 78-92%) and a specificity of 73%; (p value 0, 95%CI: 64 to 80%). The pooled accuracy was also high 88% (95%CI=85 to 91%)
Conclusions: In patients with AP, NLR is an independent prognostic factor for mortality among adults with AP. A NLR (>12), is associated with higher risk of mortality.
Keywords: Acute Pancreatitis; Mortality; Neutrophil to lymphocyte ratio. NLR.
Title: Neutrophil-Lymphocyte Ratio for Predicting Mortality among Adult Patients with Acute Pancreatitis: A Meta-Analysis
Author: Joema D. Tabanda, Allen M. Quirit, Benjamin T. Castro Jr
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Research Publish Journals
