Abstract: Obesity is a public health problem that has reached epidemic proportions with an increasing worldwide prevalence. Endothelial dysfunction represents an early phase of vascular changes that eventually lead to atherosclerosis with all its unfavorable complications. The purpose of this study was to evaluate the endothelial dysfunction and oxidative stress as potential biomarkers to assess whether these markers are considered non invasive early predication of CVD. Two groups of subjects were included in this study (obese and non obese). Serum levels of soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), E-selectin (E-selectin), oxidized LDL (oxo-LDL) and 8-iso-prostaglandinF2α (8-iso-PGF2α) were assessed by enzyme linked immunosorbent assay. In comparison with control group, a significantly elevation of serum sICAM-1, sVCAM-1, E-selectin, oxo-LDL and 8-iso-PGF2α levels (p < 0.001) in obese population as comared with none obese. In obese group, Pearson analysis showed a positive correlation between E-selectin and with albumin (r= 0.313,p= 0.036) but negative correlation between 8-iso-PGF2α and albumin (r= -0.430, p= 0.003), ICAM-1 concentration were negative correlated with T.BIL (r= -0.307, p= 0.040) and D.BIL (r= -0.324, p= 0.030) but positive correlated with AST (r= 0.323, p= 0.030) and LDH (r= 0.348, p= 0.019). Endothelial dysfunction and oxidative stress marker are significantly elevated in obese population with poor performance status.
Keywords: Obesity, oxidative stress biomarker, Saudi Arabia
Title: Non Invasive Early Predication of Endothelial Dysfunction in Obese Subjects
Author: Amal S. Al Souied, Said S.Moselhy, Safaa Qusti, Taha Kumosani, Soonham Sami Yaghmoor,
International Journal of Healthcare Sciences (IJHS)
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