Abstract: The present study was designed to investigate the cytotoxic and thrombolytic activity of ethanol extract of leaves of Elatostema papillosum. Ethanol extract of Elatostema papillosum, was used to evaluate its cytotoxicity in Brine shrimp lethality bioassay where vincristin sulphate was used as standard drug. Thrombolytic effect of the fraction was investigated in clot lysis experiment. In Brine shrimp lethality bioassay, LC50 value of the extract was 2467.13μg/mland vincristin sulphate served as the positive control showed LC50 value 10.51 μg/ml. The extract exerted 50.86%lysis of the blood clot in thrombolytic activity test while 85.25%.And7.75%lyses were obtained for positive control (streptokinase) and negative control respectively. Compared to vincristin sulphate, it is evident that the ethanol extractof leaves of Elatostema papillosum were cytotoxic. So, the extract possessed considerable thrombolytic activity. Which compounds is responsible for the present pharmacological actions and to know their mechanism of action, extensive pharmacological and phytochemical experiments are essential.
Keywords: Elatostema papillosum, Cytotoxic Activity, Thrombolytic Activity, Vincristine, Streptokinase.
Title: Study on In-Vitro Cytotoxic and Thrombolytic Activity of Ethanolic Extract of Elatostema Papillosum Leaves
Author: Naymul Karim, Md Hossan Sakib, Rana Dhar, Mohammad Shahadat Hossain, Asif Al Mahmood, Muhammad Sazzad Hossain, Sadequr Rahman
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
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