Abstract: Background: Commiphora gileadensis, a medicinal plant with traditional use, is gaining recognition in scientific research for its potential therapeutic applications. Objective: This study aimed to investigate the acute toxicity profile of Commiphora gileadensis methanolic-aqueous extract in rats, focusing on mortality, body weight changes, and hematological parameters. Methods: Rats were orally administered with varying doses of the extract, and acute toxicity was assessed by monitoring mortality and body weight changes. Hematological parameters, including leukocyte populations and red blood cell indices, were analyzed to elucidate potential systemic effects. Results: No deaths were observed in rats treated with the plant extract, and no statistically significant differences were found in body weights between the treated and control groups. In addition, no significant difference was shown in white, red blood cell counts and hemoglobin. However, the extract showed significant changes in some blood parameters, including neutrophils, lymphocytes, monocytes, eosinophils, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and red cell distribution width, platelet count, and mean platelet volume. Conclusion: This research contributes valuable insights into the acute toxicity of Commiphora gileadensis methanolic-aqueous extract, providing a foundation for future studies on its safety profile.
Keywords: Commiphora gileadensis; Methanolic-aqueous extract; Acute toxicity; LD50; Hematological parameters; Rats.
Title: Toxicological Evaluation of Commiphora gileadensis Methanolic-aqueous Extract: An Acute Toxicity Study in Rats
Author: Nesreen A. Shawush, Talal A. Zari, Dhafer A. Alzahrani
International Journal of Life Sciences Research
ISSN 2348-313X (Print), ISSN 2348-3148 (online)
Vol. 12, Issue 1, January 2024 - March 2024
Page No: 18-23
Research Publish Journals
Website: www.researchpublish.com
Published Date: 22-February-2024
