Abstract: In this article, we explain the clinical roles of CCBs in angina, dual calcium channel therapy and contraindications. We performed an electronic search through Medline, and Embase databases (up to November 2017) for publications, we limited our search to English language Articles, and to every study discussing Calcium Channels blockers (CCBs) effectiveness in angina. CCBs inhibit Ca2+ channels in the myocardium or vascular smooth muscular tissue cells, resulting in inhibition of myocardium contraction, inhibition of ICS (anti-arrhythmias) and vasodilation. Moreover, CCBs have a pleiotropic effect on CSA including alternative angina, MI and ST. Furthermore, new systems of action of Ca2+ channels, such as the aldosterone inhibition effect and mineralocorticoid receptor blockade impact, have been illuminated in the field of endocrinology. All the calcium blockers have been utilized for managing angina. Nevertheless, the most commonly utilized calcium blockers are the longer-acting types of diltiazem and verapamil, amlodipine, or felodipine.
Keywords: Calcium Channels blockers (CCBs), effectiveness in angina.
Title: Use of Two Agents Calcium Channels Blockers (CCBs) In Angina
Author: Mamdouh Eidhah Alharthi, Ahmad Othman Almailabi, Ahmed Taher Altayeb
International Journal of Healthcare Sciences
ISSN 2348-5728 (Online)
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